Zearalenone Induced Cytotoxicity and Oxidative Stress in Human Peripheral Blood Leukocytes

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Martha Josefina Viera-Limón1, Jesús Antonio Morlett-Chávez2, Crystel Aleyvick Sierra-Rivera3, Diana Luque-Contreras2 and Alejandro Zugasti-Cruz1,3*

1 Food Research Department, Faculty of Chemistry, Autonomous University of Coahuila, Mexico
2 Molecular Diagnosis and Clinical Analyses Laboratory, Faculty of Chemistry, Autonomous University of Coahuila, Mexico
3 Laboratory of Immunology, Faculty of Chemistry, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico.

*alejandro_zugasti@uadec.edu.mx

Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by a variety of Fusarium fungi that are
commonly found in feed. ZEA cause reproductive disorders of farm animals and occasionally hyperoestrogenic
syndromes of humans; also, has been shown to be hepatotoxic, genotoxic, hematotoxic and immunotoxic, evidence
primarily based on studies with different biological models in vitro and in vivo in poultry and laboratory rodents.
However, there is little knowledge about of the effects of ZEA in human leukocytes.

11 ART 2015 Zearalenone


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