Síntesis de derivados nitrogenados de naftoquinona y su evaluación biológica. Formulación de una película funcional


Facultad de Ciencias Químicas

Ing. Laura Ramos Peralta

Abstract: Natural and synthetic naphthoquinone are an important group because they have shown important  biological activities such as antibacterial, antifungal, antiviral, anticancer, antiparasitic, and others. In the present thesis is reported the synthesis of the compounds 2(2,4-dichloroanilino)-1,4-naphthoquinone (3a), 2-(2,4 difluroanilino)-1,4-naphthoquinone (3b), and 2-(anilino)-1,4-naphthoquinonena (3c), by the 1,4-type Michael addition of three aromatic amines (2,4-dichloroaniline/2,4-difluoroaniline/aniline) to 1,4-naphthhoquinone ring, using three different methodologies: the Room Temperature Synthesis (RTS), Ultrasound Assisted Synthesis (UAS), and Microwave Assisted Synthesis (MAS), the first a conventional method, and the second are considerate green methodologies that use alternative sources of activation in the organic reactions under the principles of green chemistry to related with the energetic efficient. The structure compounds was determinate by spectroscopy of IR, C NMR. Antibacterial and antifungal activities were performed to the compounds, and as well as the hemolysis and Artemia salina toxicity assays. Moreover the antioxidant activity using DPPH method was determinate. Finally these compounds were incorporated to an edible shell generated from pectin, candelilla wax and glycerol and was characterized by measuring parameters such as thickness, water vapor permeability, solubility and transparency.

Thesis Laura Ramos Peralta