Osteoarthritis (OA) of the knee causes disability, pain, and progressive destruction of cartilage in adult women.
The objective of the study was to evaluate the concentrations of the urinary biomarker C-terminal telopeptide of
type II collagen (CTX-II) and pain by radiographic grade in women with knee OA in northeastern Mexico: Crosssectional study of 155 women with knee OA. Concentrations of biochemical parameters were evaluated and
urine samples were collected to measure biomarker levels (uCTX-II) ng/mmol by competitive enzyme-linked
immunoabsorbent assay (ELISA) technique and the Western Ontario and McMaster Universities Osteoarthritis
Index (WOMAC) scale was used for pain classification; median age of 49 years and 29.1 kg/m2 of body mass
index (BMI). uCTX-II biomarker levels were grade 2 (210.7 ng/mmol), grade 3 (314.8 ng/mmol), and grade 4
(478.8 ng/mmol) relative to Kellgren and Lawrence, uCTX-II levels were compared with WOMAC scale and presented significant statistical difference (p = 0.0001). An association of the biomarker CTX-II and an increase in BMI was found in female patients with knee OA (odds ratio = 1.01; 95% confidence interval 1.001–1.005; p = 0.047).This study demonstrates an increase in the levels of the biomarker uCTX-II, the degree of pain, and radiographic grade in women with knee OA in northeastern Mexico.