Castela texana (Torr. & A. Gray) Rose is a native plant to the arid regions of northern Mexico, whose medicinal
properties includes antipyretic, antiparasitic, antibacterial and immunomodulatory activity. The objective of this work was to evaluate the immunomodulatory activity of the methanolic-extract of Castela texana leaf on the production of nitric oxide in murine peritoneal macrophages, since these cells are the major players of the first line of defense of the immune response.
The citotoxicity of Castela texana methanolic-extracts (10, 100 and 1000 μg/mL) was evaluated with a haemolytic activity model.