Lizeth Martinez-Jacobo 1, 2, 6; Claudia I. Ancer-Arellano c; Rocio Ortiz-Lopez 2, 4; Mauricio Salinas-Santander 5; Cesar Daniel Villarreal-Villarreal 3; Jesus Ancer-Rodriguez 2; Bianka Camacho-Zamora 1, 2; Viviana Zomosa-Signoret 1; Carlos E. Medina-De la Garza 2; Jorge Ocampo-Candiani 3; Augusto Rojas-Martinez 2, 4
1 Universidad Autonoma de Nuevo Leon, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina,
2 Centro de Investigación y Desarrollo en Ciencias de la Salud, UANL,
3 Servicio de Dermatología, Hospital Universitario, UANL,
4 Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud,
5 Universidad Autonoma de Coahuila, Facultad de Medicina, Departamento de Investigacion, Saltillo, and
6 Universidad de Monterrey, Vicerrectoría de Ciencias de la Salud, Departamento de Ciencias Básicas, San Pedro Garza García, Mexico
*augusto.rojasmtz @ itesm.mx
Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early
stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.
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