CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico

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Mauricio Andrés Salinas-Santander 1,∗, Cristina Susana Cantu-Salinas 2, Jorge Ocampo-Candiani 2, Victor de Jesus Suarez-Valencia 1, Jennifer Guadalupe Ramirez-Guerrero 1, Celia Nohemi Sanchez-Dominguez 3.

1 Department of Investigation, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila, Mexico
2 Dermatology Service, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico
3 Department of Biochemistry and Molecular Medicine, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, Mexico

*E-mail: msalinsa@yahoo.com

Background
Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial.

Objective
The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population.

Methods
We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP.

Results
No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p > 0.05). Study limitations: Small sample size of patients and the data were obtained from Northeast Mexico population.

Conclusion
The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population.

2 CTLA4 ALopecia_Anais_Bras-s2.0-S0365059620300921-main


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