Aims: (1) To evaluate the association between type 2 diabetes mellitus (T2D) and primary knee osteoarthritis
(KOA); and (2) to compare synovial fluid (SF) cartilage oligomeric matrix protein (COMP) concentrations and
glycemic control parameters in patients with T2D, with and without primary KOA.
Methods: A total of 231 individuals were included in this study. Primary KOA was confirmed according to the
criteria established by the American College of Rheumatology. The presence of T2D was determined by medical
history. In addition, fasting plasma glucose and glycated hemoglobin were analyzed to confirm diabetic and nondiabetic status.
Results: Our results showed an association between T2D and primary KOA after covariate adjustments
(OR= 3.755, p = 0.000024, 95% CI: 2.033–6.934). In addition, SF COMP levels were significantly higher in T2D
groups with and without primary KOA ( p = 0.00035; p = 0.001 respectively) when compared to nonT2D controls.
Conclusion: This study suggests a strong association between T2D and primary KOA; in addition, the presence
of T2D may have an influence in SF COMP levels in subjects with and without primary KOA. The glycemic
control parameters and duration of diabetes may be useful as an indirect indicator of SF COMP levels to prevent
the effects of chronic exposure to hyperglycemia and subsequent damage to the articular cartilage.