Aims: To investigate the possible roles of the single nucleotide polymorphisms (SNPs) MATN3 (rs77245812)
and DOT1L (rs12982744) with susceptibility to knee osteoarthritis (KOA) among mestizos from the northeast
region of Mexico. In addition, we analyzed the relationship of their urinary levels of carboxy terminal telopeptide
of collagen type II (CTX-II) and the radiological grade of disease.
Materials and Methods: A total of 223 individuals from a Northeast Mexico Mestizo population were included
in this study: 110 patients with primary KOA and 113 healthy controls. Genotyping of the MATN3 (rs77245812)
and DOT1L (rs12982744) SNPs was performed by real-time polymerase chain reaction.
Results: No association was found between the polymorphisms MATN3 (rs77245812), DOT1L (rs12982744),
and the risk of developing KOA (odds ratio [OR] = 1.33, 95% conﬁdence interval [CI] = 0.42–6.48, p = 0.621)
(OR = 2.03, 95% CI = 0.35–11.5, p = 0.422). However, urinary CTX-II levels were considerably higher by
Conclusions: An increase in CTX-II per radiographic grade was observed in the case group, but no association
was found between MATN3 and DOT1L genes and the risk of KOA in Mexican mestizos.