Aims: To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1
(rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico.
Methods: A total of 296 individuals were included in the study. Primary KOA was conﬁrmed according to the
criteria established by the American College of Rheumatology. A real-time PCR-based DNA genotyping
method was used to evaluate the rs3740199, rs1871054, and rs2073508 polymorphisms in 132 cases and 164
Results: Our results demonstrate that the ADAM12 rs3740199 polymorphism was signiﬁcantly associated with
primary KOA under the recessive model ( p = 0.036). However, after performing a multinomial logistic regression model, no signiﬁcant association was found ( p = 0.722). Furthermore, no associations for the rs1871054 and rs2073508 polymorphisms were observed in this study.
Conclusion: These ﬁndings suggest that polymorphisms within the ADAM12 and TGFB1 genes may not have a
signiﬁcant inﬂuence on primary KOA susceptibility in the Mexican Mestizo population; however, inclusion of
other ethnic groups and a larger sample size are needed to more fully analyze the role of these polymorphisms
with KOA risk.