ABSTRACT: The Allele Frequency Net Database (AFND, www.allelefrequencies.net) provides the scientiﬁc community with a freely available repository for the storage of frequency data (alleles, genes, haplotypes and genotypes) related to human leukocyte antigens (HLA), killer-cell immunoglobulin-like receptors (KIR), major histocompatibility complex Class I chain related genes (MIC) and a number of cytokine gene polymorphisms in worldwide populations. In the last ﬁve years, AFND has become more popular in terms of clinical and scientiﬁc usage, with a recent increase in genotyping data as a necessary component of Short Population Report article submissions to another scientiﬁc journal. In addition, we have developed a user-friendly desktop application for HLA and KIR genotype/population data submissions. We have also focused on classiﬁcation of existing and new data into ‘gold–silver–bronze’ criteria, allowing users to ﬁlter and query depending on their needs. Moreover, we have also continued to expand other features, for example focussed on HLA associations with adverse drug reactions. At present, AFND contains >1600 populations from >10 million healthy individuals, making AFND a valuable resource for the analysis of some of the most polymorphic regions in the human genome.
2020 Allele frequency net database AFND 2020 update gold-standard data classification open access genotype data and new query tools 2020 Allele frequency net database AFND 2020 update gold-standard data classification open access genotype data and new query tools