Rubén García Garza

Journal of Medicinal Plants Research Testicular damage in Wistar rats caused by methanolic extracts of plants from the North of Mexico..

The aim of this study was to evaluate the effect of methanolic extract of plants from the north of Mexico, on testicular morphology and spermatic quality in Wistar rats. Methanolic extracts were orally administered to 4…

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Liver damage in an experimental model of peripheral neuropathy induced by Karwinskia humboldtiana (Buckthorn) fruit: Histopathological evidence..

Karwinskia humboldtiana (Kh) is a poisonous shrub that causes acute or chronic intoxication in animals and humans. In chronic intoxication, the main sign is the presence of paralysis. Previously we reported a model of intoxication with…

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Fast acetone tissue processing of human organs provides tissue characteristics equal to conventional processing.

Routine preparation of paraffin embedded tissue for histopathological diagnosis, here termed conventional histological technique (CT), whether performed manually or using an automated system, requires approximately 12 h. We developed earlier a rapid acetone dehydration technique (AT)…

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Peroxisomicine A1 (Toxin T-514) induces cell death of hepatocytes in vivo by triggering the intrinsic apoptotic pathway.

Karwinskia parvifolia possesses the highest concentration levels of the anthracenone T-514 (PA1). Studies have demonstrated the induction of apoptosis by PA1 in cancer cell lines. The aim was to investigate the effects of PA1 on the…

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The matrix synthesis and anti-inflammatory effect of autologous leukocyte-poor platelet rich plasma in human cartilage explants.

To determine the effects of autologous leukocyte-poor platelet-rich plasma (LPPRP) on the expression of markers involved in cartilageextracellular matrix production and inflammation in cartilage explants bearing osteoarthritis. Cartilage explants and LP-PRP were obtained from 10 patients…

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Invasion of TC-1 cells to skeletal muscle fibers protect them from peroxisomicine A1 (T-514) treatment in a murine model of cancer.

T-514 or Peroxisomicine A1 (PA1) is a toxin isolated from plants of genus Karwinskia. In vitro studies described selective toxicity of PA1 on malignant cell lines. A toxic effect of PA1 on TC-1 cells in vivo…

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IMMUNOMODULATORY ACTIVITY OF CASTELA TEXANA METHANOLICEXTRACT ON THE PRODUCTION OF NITRIC OXIDE IN MURINE MACROPHAGES.

Castela texana (Torr. & A. Gray) Rose is a native plant to the arid regions of northern Mexico, whose medicinal properties includes antipyretic, antiparasitic, antibacterial and immunomodulatory activity. The objective of this work was to evaluate…

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All-trans retinoic acid improves pancreatic cell proliferation on induced type 1 diabetic rats.

ABSTRACT: All-trans retinoic acid (ATRA) has been extensively studied as an integrating component of endocrine functions in the pancreas. The aim of this study was to evaluate the effects of ATRA on physiopathological biomarkers in an…

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Evaluación de la Actividad Antioxidante de Cnidoscolus chayamansa (Chaya), Euphorbia prostrata (Hierba de la Golondrina) y Jatropha dioica (Sangre de Drago) en Ratas Wistar Inducidas a Hiperglicemia.

Estudios recientes han demostrado que los compuestos activos presentes en extractos de C. chayamansa, E. prostrata y J. dioica tienen propiedades antioxidantes. Los resultados obtenidos en nuestro estudio fueron compuestos fenólicos solubles mostraron en C. chayamansa…

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Evaluation of the Coating with TiO2 Nanoparticles as an Option for the Improvement of the Characteristics of NiTi Archwires: Histopathological, Cytotoxic, and Genotoxic Evidence.

For the EPD, diferent voltages and diferent times were used. Male rats were used in four groups (�=3) with diferent treatments. Te blood sample was obtained for genotoxic analysis and liver and kidney organs were removed…

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